SOME IMPORTANT SYNDROMES Peutz-Jeghers syndrome Peutz-Jeghers syndrome (PJS) is a disorder often passed down through families (inherited) in which the person develops intestinal polyps and is at a significantly higher risk for developing certain cancers. Causes It is unknown how many people are affected by PJS. However, the National Institutes of Health estimates that it affects about 1 in 25,000 to 300,000 births. There are two types of PJS: Familial PJS is due to a mutation in a gene called STK11. The genetic defect is passed down (inherited) through families as an autosomal dominant trait. That means if one of your parents has this type of PJS, you have a 50:50 chance of inheriting the bad gene and having the disease. Sporadic PJS is not passed down through families and appears unrelated to the STK11 gene mutation. Symptoms Brownish or bluish-gray pigmented spots on the lips, gums, inner lining of the mouth, and skin Clubbed fingers or toes Cramping pain in the...
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